Muro Leccese has ancient origins, which are authentic numerous menhir, megalithic walls, evidence of Bronze Age and Neolithic settlements confirm the presence of the previous era messapica.

The first inhabitants were historically verified, however, the Messapians, people coming dall'Iliria that, starting from the sixth century BC, transformed the town into a center of urban character with houses lined up along the streets regularly.

A wall of squared blocks, 4 km long enclosing an area of just over 100 acres, and a necropolis, make it ascend to the foundation Pelasgians of Crete.

Next to Oria, Rudiae and Ugento, Muro Leccese is one of the major of Messapia, and certainly the largest in the territory occupied by Vaste, Otranto and Castro, which is a few kilometers.

The inscriptions and language messapica old materials, from Muro Leccese and maintained at the Provincial Museum of Lecce, give further evidence on the role played by this anonymous town in Salento Messapico, completely destroyed by Roman troops in the third century A.C.

The events of the farmhouse fortress rebuilt after this devastation, are insignificant, except for the news, not completely verified, he wants Muro was destroyed in 924 by the Saracens in their raids in Salento territory, and in 1156, was razed to the ground by the Teutonic robber Guglielmo il Malo.

The Norman Tancredi it favored the reconstruction after entrusting it in fief to Captain Alessandro Choti.

The Swabian domination and fierce repression operated by Enrico VI during the Norman conquest of the territories left Muro and Salento in desolation. In the fief of the Angevin period belonged to the lineage of Muro a de Monti Marquis of Corigliano d'Otranto, who disappeared from Muro after more than a century of the principality, at the same time when the meteor vanished Anjou.

At the end of the fourteenth century, under Carlo III di Durazzo (1345-1386), Muro was reserved to the Crown.

After of the turbulent events of Durazzo, Muro passed to the Orsini del Balzo principles of Taranto, who staked the boundaries of the manor in 1438, to Protonobilissimo, house of origins Tarantino. They were princes of Muro until 1774, when the city passed to the State.

In 1797 the estate was granted by King Ferdinando to Prince Antonio Maria Pignatelli di Belmonte: this family held the estate until 1854, when then sell it to the Knight Achille Tamborino.

The following is recent history that will see Muro, after the unification of Italy, follow with courage and lively participation the changing fortunes and destinies of the entire nation.

Of particular interest are:

The Church of San Domenico: with the adjoining convent, built in the years 1561-1583;

The Chapel of the Crucifix: built in 1573 on the ruins of a very old building;

The Protonobilissimo Castle: remodeled several times;

The Church of the Immaculate Conception: dating back to 1778, which features a beautiful Baroque facade and fine sculptures and magnificent altars preserved;

The Mother Church: adorned with a magnificent portal and a comprehensive and harmonious façade, built between 1680 and 1693, which houses inside the works of the painter Liborio Riccio and Serafino Elmo.